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國家衛(wèi)健委功能性腦疾病診治重點(diǎn)實(shí)驗(yàn)室

基本情況

重慶醫(yī)科大學(xué)附屬第一醫(yī)院神經(jīng)內(nèi)科醫(yī)師?，F(xiàn)擔(dān)任中國醫(yī)藥教育協(xié)會神經(jīng)免疫專業(yè)委員會 委員、重慶市醫(yī)師協(xié)會神經(jīng)免疫學(xué)組委員。

研究方向(含承擔(dān)課題)

主要研究領(lǐng)域?yàn)橐钟舭Y發(fā)生過程中代謝物和蛋白質(zhì)紊亂的病理生理機(jī)制及發(fā)掘有效臨床診斷標(biāo)志物。以第一作者/通訊作者在Journal of Advanced Research、SCIENCE CHINA Life Sciences、Translational Psychiatry (4篇)、Communications Biology、Journal of Affective Disorders等發(fā)表12篇SCI論文。主持國家自然科學(xué)基金1項(xiàng)、中國博士后科學(xué)基金特別資助1項(xiàng)、中國博士后科學(xué)基金面上項(xiàng)目1項(xiàng)、重慶市博士后特別資助項(xiàng)目1項(xiàng)、重慶市自然科學(xué)基金1項(xiàng)、重慶醫(yī)科大學(xué)附屬第一醫(yī)院博士后資助項(xiàng)目1項(xiàng)；參與重慶醫(yī)科大學(xué)未來醫(yī)學(xué)青年創(chuàng)新團(tuán)隊1項(xiàng)。申請國家發(fā)明專利4項(xiàng)。

著作論文

1. Xu K, Wang M, Wang H, Zhao S, Tu D, Gong X, Li W, Liu X, Zhong L, Chen J, Xie P. HMGB1/STAT3/p65 axis drives microglial activation and autophagy exert a crucial role in chronic Stress-Induced major depressive disorder. J Adv Res. 2024 May;59:79-96.

2. Xu K, Zhao S, Ren Y, Zhong Q, Feng J, Tu D, Wu W, Wang J, Chen J, Xie P. Elevated SCN11A concentrations associated with lower serum lipid levels in patients with major depressive disorder. Transl Psychiatry. 2024 May 11;14(1):202.

3. Xu K, Ren Y, Zhao S, Feng J, Wu Q, Gong X, Chen J, Xie P. Oral D-ribose causes depressive-like behavior by altering glycerophospholipid metabolism via the gut-brain axis. Commun Biol. 2024 Jan 9;7(1):69.

4. Xu K, Ren Y, Fan L, Zhao S, Feng J, Zhong Q, Tu D, Wu W, Chen J, Xie P. TCF4 and RBFOX1 as peripheral biomarkers for the differential diagnosis and treatment of major depressive disorder. J Affect Disord. 2024 Jan 15;345:252-261.

5. Xu K, Zhou X, Ren Y, Zhao S, Feng J, Zhang H, Zhong Q, Wu W, Chen J, Xie P. IDH2/PPARγ pathway as a novel diagnostic biomarker panel for schizophrenia. Asian J Psychiatr. 2023 Nov;89:103788.

6. Xu K, Zheng P, Zhao S, Wang J, Feng J, Ren Y, Zhong Q, Zhang H, Chen X, Chen J, Xie P. LRFN5 and OLFM4 as novel potential biomarkers for major depressive disorder: a pilot study. Transl Psychiatry. 2023 Jun 6;13(1):188.

7. Xu K, Zheng P, Zhao S, Feng J, Pu J, Wang J, Zhao S, Wang H, Chen J, Xie P. Altered MANF and RYR2 concentrations associated with hypolipidemia in the serum of patients with schizophrenia. J Psychiatr Res. 2023 Jul;163:142-149.

8. Xu K, Zheng P, Zhao S, Wang M, Tu D, Wei Q, Feng J, Wang H, Chen J, Xie P. MANF/EWSR1/ANXA6 pathway might as the bridge between hypolipidemia and major depressive disorder. Transl Psychiatry. 2022 Dec 30;12(1):527.

9. Xu K, Wang M, Zhou W, Pu J, Wang H, Xie P. Chronic D-ribose and D-mannose overload induce depressive/anxiety-like behavior and spatial memory impairment in mice. Transl Psychiatry. 2021 Feb 2;11(1):90.

10. Xu K, He Y, Chen X, Tian Y, Cheng K, Zhang L, Wang Y, Yang D, Wang H, Wu Z, Li Y, Lan T, Dong Z, Xie P. Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice. J Neurochem. 2019 Jun;149(6):799-810.

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