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國家衛(wèi)健委功能性腦疾病診治重點(diǎn)實(shí)驗(yàn)室

研究方向(含承擔(dān)課題)

專注于腦出血損傷機(jī)制和神經(jīng)影像學(xué)研究。在前期腦出血臨床序貫研究基礎(chǔ)上,旨在以降低腦出血死亡率致殘率為總體目標(biāo),利用深度學(xué)習(xí)、個(gè)體化功能圖譜等技術(shù),構(gòu)建腦出血臨床-分子-影像風(fēng)險(xiǎn)預(yù)警模型。結(jié)合腦出血后腦損傷關(guān)鍵機(jī)制及靶標(biāo),建立腦出血一體化智慧診療體系,助力提高我國腦出血防治綜合水平。

著作論文

1. Luo S#, Yang WS#, Shen YQ#, Chen P, Zhang SQ, Jia Z, Li Q, Zhao JT, Xie P. The clinical value of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and D-dimer-to-fibrinogen ratio for predicting pneumonia and poor outcomes in patients with acute intracerebral hemorrhage. Front Immunol. 2022; 13: 1037255.

2. Yang WS#, Shen YQ#, Yang X#, Li XH, Xu SH, Zhao LB, Li R, Xiong X, Bai SJ, Wu QY, Manaenko A, Li Q, Xie P. MicroRNA Transcriptomics Analysis Identifies Dysregulated Hedgehog Signaling Pathway in a Mouse Model of Acute Intracerebral Hemorrhage Exposed to Hyperglycemia. J Stroke Cerebrovasc Dis. 2022 Mar;31(3):106281.  

3. Shen YQ#, Yang WS#, Xiong X, Li XH, Xiao ZS, Yu JL, Liu FY, Gui SW, Xie XF, Lv FJ, Zhao LB, Hu LB, Manaenko A, Xie P, Li Q. Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage. Oxidative Medicine and Cellular Longevity, 2021, 2021: 1-20.

4. Yang WS#, Shen YQ#, Zhang XD#, Zhao LB, Wei X, Xiong X, Xie XF, Li R, Deng L, Li XH, Lv XN, Lv FJ, Li Q, Xie P. Hydrocephalus Growth: Definition, Prevalence, Association with Poor Outcome in Acute Intracerebral Hemorrhage. Neurocrit Care. 2021 Aug;35(1):62-71.

5. Yang WS#, Shen YQ#, Wei X, Zhao LB, Liu QJ, Xie XF, Zhang ZW, Deng L, Lv XN, Zhang SQ, Li XH, Li Q, Xie P. New Prediction Models of Functional Outcome in Acute Intracerebral Hemorrhage: The dICH Score and uICH Score. Front Neurol. 2021 May 5;12:655800.  

6. Yang WS#, Li R#, Shen YQ#, Wang XC, Liu QJ, Wang HY, Li Q, Yao GE, Xie P. Importance of lipid ratios for predicting intracranial atherosclerotic stenosis. Lipids Health Dis. 2020 Jul 4;19(1):160.

7. Li Q#, Shen YQ#, Xie XF#, Xue MZ, Cao D, Yang WS, Li R, Deng L, Lv FJ, Wu GF, Tang ZP, Xie P. Expansion-Prone Hematoma: Defining a Population at High Risk of Hematoma Growth and Poor Outcome. Neurocrit Care, 2019 Jun;30(3):601-608.  

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