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國家衛(wèi)健委功能性腦疾病診治重點實驗室

研究方向(含承擔(dān)課題)

主要從事抑郁障礙分子和神經(jīng)環(huán)路機(jī)制研究?;谏窠?jīng)炎癥、代謝紊亂等角度挖掘抑郁障礙的重要致病分子機(jī)制,并結(jié)合環(huán)路示蹤、神經(jīng)細(xì)胞活動及調(diào)控技術(shù)解析抑郁障礙治病的神經(jīng)環(huán)路機(jī)制,尋找抑郁障礙潛在的干預(yù)新靶點。以第一作者、通訊作者(含共同)發(fā)表SCI論文10篇。國家授權(quán)發(fā)明專利1項。博士后期間主持中國博士后科學(xué)基金項目、重慶市博士后科學(xué)基金項目、重慶市博士后特別資助項目,并合作主持重慶醫(yī)科大學(xué)未來醫(yī)學(xué)青年創(chuàng)新團(tuán)隊項目。

著作論文

1. Yue Wang#, Xiangyu Chen#, Zhi Chen, Heming Yu, Yu Tian, Yong He, Ke Cheng*, Peng Xie*. Disturbances of phosphatidylcholines metabolism in major depressive disorder. CNS Spectr. 2023, 28(5):637-645. doi: 10.1017/S1092852923000020.

2. Yue Wang#, Yan Li#, Zhonghao Wu#, Zhi Chen#, Heming Yu, Yong He, Yu Tian, Tianlan Lan, Mengge Bai, Xiangyu Chen, Ke Cheng*, Peng Xie*. Ferritin disorder in the plasma and hippocampus associated with major depressive disorder. Biochemical and Biophysical Research Communications, 2021,553:114-118.  

3. Yue Wang, Liming Liu, Hengsheng Chen, Li Cheng, Li Jiang*. Influence of the epileptiform discharge microenvironment on the differentiation of oligodendrocyte precursor cells. Brain Research, 2018, 1679:53–63.  

4. Jiashan Xia, Jiayu Wang, Fengyuan Liu, Zhiqiong Chen, Changmei Chen, Xiangshu Cheng, Yu Chao*, Yue Wang*, Tao Deng*Red/NIR-I-Fluorescence Carbon Dots Based on Rhein with Active Oxygen Scavenging and Colitis Targeting for UC TherapAdv. Healthcare Mater. 2024, 2304674.

5. Yong He#Yue Wang#, Heming Yu, Yu Tian, Xiangyu Chen, Chong Chen, Yikun Ren, Zhi Chen, Yi Ren, Xue Gong, Ke Cheng, Xiaolei Liu, Lianmei Zhong*, Yi Guo*, Peng Xie*. Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex. Pharmacol Res. 2023, 191:106717.

6. Ke Cheng#Yue Wang#, Yong He#, Yu Tian#, Junjie Li#, Chong Chen, Xingzhe Xu, Zhonghao Wu, Heming Yu, Xiangyu Chen, Yili Wu, Weihong Song*, Zhifang Dong*, Huatai Xu*, Peng Xie*.Upregulation of carbonic anhydrase 1 beneficial for depressive disorder. Acta Neuropathol Commun. 2023 11(1):59.

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