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國家衛(wèi)健委功能性腦疾病診治重點實驗室

研究方向(含承擔(dān)課題)

專注于腦內(nèi)膠質(zhì)細(xì)胞對腸道微生物代謝的響應(yīng)機制,基于腸道微生物的抑郁癥診斷體系的開發(fā)。近五年主持國家自然科學(xué)基金,青年科學(xué)基金項目1項。

著作論文

1. Wu J#, Li YF#, Huang Y#, Liu LX, Zhang HP, Corina Nagy, Tan XM, Cheng K, Liu YY, Pu JC, Wang HY, Wu QY, Seth W. Perry, Gustavo Turecki, Ma-Li Wong, Julio Licinio, Zheng P*, Xie P*. Integrating spatial and single-nucleus transcriptomic data elucidates microglial-specific responses in female cynomolgus macaques with depressive-like behaviors. Nat Neuroscience. (2023)

2. Huang Y#Wu J#, Zhang H, Li Y, Wen L, Tan X, Cheng K, Liu Y, Pu J, Liu L, Wang H, Li W, Perry SW, Wong ML, Licinio J, Zheng P*, Xie P*. The gut microbiome modulates the transformation of microglial subtypes. Mol Psychiatry. (2023)

3. Zheng P#., Wu J#., Zhang H., Perry S. W., Yin B., Tan X., Chai T., Liang W., Huang Y., Li Y., Duan J., Wong M. L., Licinio J., Xie P*. The gut microbiome modulates gut-brain axis glycerophospholipid metabolism in a region-specific manner in a nonhuman primate model of depression. Mol Psychiatry (2021) 26(6):2380-2392

4. Wu, Jing; Chai, Tingjia; Zhang, Hanping; Huang, Yu; Seth W. Perry; Li, Yifan; Duan, Jiajia; Tan, Xunmin; Hu, Xi; Liu, Yiyun; Pu, Juncai; Wang, Haiyang; Song, Jinlin; Ji, Ping; Zheng, Peng; Xie, Peng ; Changes in gut viral and bacterial species correlate with altered 1,2-diacylglyceride levels and structure in the prefrontal cortex in a depression-like non-human primate model, Translational Psychiatry, 2022, 12(1): 74

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