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國家衛(wèi)健委功能性腦疾病診治重點實驗室

研究方向(含承擔課題)

長期從事博爾納病病毒導致神經(jīng)精神疾病發(fā)生發(fā)展的研究工作。主持和參與重慶市技術(shù)創(chuàng)新與應用發(fā)展項目1項，重慶市自然科學基金博士后項目2項（已結(jié)題1項）。作為主要完成人，研究相關(guān)成果獲得貴州省科技進步二等獎（2019年），重慶市科技進步一等獎（2020年）。

著作論文

1. Xu X, Guo Y, Tang T, Sun L, Zhang X, Shen X, Li D, Wang L, Zhao L, Xie P. miR-505 inhibits replication of Borna disease virus 1 via inhibition of HMGB1-mediated autophagy, Journal of General Virology, 2022, 103(1).

2. Xu X, Tang T, Guo Y, Zhao L, Shen X, Sun L, Xie P. BoDV-1 infection induces neuroinflammation by activating the TLR/ MyD88/IRF5 signaling pathway, leading to learning and memory impairment in rats, J Med Virol, 2021, 93(11)

3. Xu X, Jie J, Xia J, Tu Z, Guo Y, Li C, Zhang X, Wang H, Song W, Xie P. Memory Impairment Induced by Borna Disease Virus 1 Infection is Associated with Reduced H3K9 Acetylation, Cell Physiol Biochem, 2018, 49(1): 381- 394.

4. Xu X, Li C, Zhang X, Cheng K, Guo Y, Jie J, Guo H, He Y, Zhou C, Gui S, Zhong X, Wang H, Xie P. Activation of ERK/CREB/BDNF pathway involved in abnormal behavior of neonatally Borna virus-infected rats, Neuropsychiatr Dis Treat, 2018, 14: 3121-3132.

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