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國家衛(wèi)健委功能性腦疾病診治重點實驗室

基本情況

重慶醫(yī)科大學(xué)附屬第一院，國家衛(wèi)健委功能性腦疾病診治重點實驗室，高級實驗師。

研究方向(含承擔(dān)課題)

多年從事無菌小鼠的研究工作，主要方向是利用無菌小鼠探索菌群與疾病關(guān)系的研究，目前基于解析機體自身基因組功能與腸道菌群宏基因組功能的相互關(guān)系，形成了無菌小鼠人工哺乳、遺傳工程小鼠無菌化等模型動物制備體系，建成了一定規(guī)模的無菌小鼠平臺，參與關(guān)于菌群與神經(jīng)類疾病、代謝性疾病、免疫性疾病等相關(guān)性研究。

著作論文

1. Li W, Yan H, Hui D, Yi X, Gut microbiota can transfer fiber characteristics and lipid metabolic profiles of skeletal muscle from pigs to germ-free mice. Scientific Reports, 2016, 6:31786.

2. Zheng P,  Zeng B, Zhou C, Liu M, Fang Z, Xu X, Zeng L, Chen J, Fan S, Du X, Zhang X, Yang D, Yang Y, Meng H, Li W, N D Melgiri, J Licinio, Wei H, Xie P, Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism, Molecular Psychiatry, 2016, 21(6).

3. Wang H, Liu L, Rao X, Chai T, Zeng B, Zhang X, Yu Y, Zhou C, Pu J, Zhou W, Li W, Zhang H, Wei H, Xie P, Commensal Microbiota Regulation of Metabolic Networks During Olfactory Dysfunction in Mice, Neuropsychiatr Dis Treat, 2020, 2020(16): 761-769.

4. Liu L, Wang H, Rao X, Yu Y, Li W, Zheng P, Zhao L, Zhou C, Pu J, Yang D, Fang L, Ji P, Song J, Wei H, Xie P, Comprehensive analysis of the lysine acetylome and succinylome in the hippocampus of gut microbiota-dysbiosis mice, Journal of Advanced Research, 2021, 2021(30): 27-38.

5. Yu Y, Wang H, Rao X, Liu L, Zheng P, Li W, Zhou W, Chai T, Ji P, Song J, Wei H, Xie P, Proteomic Profiling of Lysine Acetylation Indicates Mitochondrial Dysfunction in the Hippocampus of Gut Microbiota-Absent Mice, Front Mol Neurosci. 2021, 14: 594332.

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