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國家衛(wèi)健委功能性腦疾病診治重點(diǎn)實(shí)驗(yàn)室

Philipp Khaitovich
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基本情況

Philipp Khaitovich（菲利普·哈伊托維奇）博士，俄羅斯斯科爾科沃科學(xué)與技術(shù)研究所神經(jīng)生物學(xué)和大腦康復(fù)中心主任，德國馬普協(xié)會(huì)進(jìn)化人類學(xué)研究所資深研究員。先后主持中國科學(xué)院戰(zhàn)略性先導(dǎo)科技專項(xiàng)（B類）、國家自然科學(xué)基金國際（地區(qū)）合作與交流項(xiàng)目、國家重點(diǎn)研發(fā)計(jì)劃子課題等科研項(xiàng)目。 在Science, Nature Neuroscience等國際頂尖雜志發(fā)表SCI論文107篇?，F(xiàn)任PLoS Biology，BMC Genomics國際刊物編委。入選2012年中組部“外專千人”計(jì)劃，獲國家“友誼獎(jiǎng)”（2013），中俄國家“友誼獎(jiǎng)”（2015），上海市“白玉蘭紀(jì)念獎(jiǎng)”（2013），中國科學(xué)院青年科學(xué)家國際合作獎(jiǎng)

研究方向(含承擔(dān)課題)

主要研究包括：（1）通過多組學(xué)整合，研究人腦從發(fā)育到衰老過程中的分子和調(diào)控機(jī)制；（2）通過比較人類和近緣靈長類動(dòng)物腦部在發(fā)育衰老全過程中的轉(zhuǎn)錄組、代謝組、脂質(zhì)組等多種分子水平的變化，鑒定人腦特有的分子變化特征并據(jù)此探索人腦特有功能的進(jìn)化機(jī)制；（3）通過比較健康人腦和具有認(rèn)知相關(guān)疾病人腦在多種組學(xué)上的差異，研究人腦發(fā)達(dá)認(rèn)知能力形成的分子機(jī)制。通過構(gòu)建人腦和靈長類大腦動(dòng)態(tài)進(jìn)化發(fā)育的高維圖譜，將有助于對(duì)已有的神經(jīng)生物學(xué)成果進(jìn)行整合，進(jìn)而對(duì)深入了解大腦的功能。

著作論文

1. Tkachev, A., Stekolshchikova, E., Vanyushkina, A., Zhang, H., Zhou, C., Liu, Y., Pu, J., Falkai, P., Kostyuk, G., Klyushnik, T., Schulze, T.G., Xie, P., Schulte, E.C., Khaitovich, P*. Lipid alteration signature in the blood plasma of individuals with schizophrenia, depression, and bipolar disorder. JAMA Psychiatry 80 (2023), 250-259. IF: 25.937

2. Khrameeva, E., Kurochkin, I., Han, D., Guijarro, P., Kanton, S., Santel, M., Qian, Z., Rong, S., Mazin, P., Sabirov, M., Bulat, M., Efimova, O., Tkachev, A., Guo, S., Sherwood, C.C., Camp, J.G., Paabo, S., Treutlein, B., Khaitovich, P*. Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains. Genome Res 30 (2020), 776-789. IF: 11.093

3. Yu, Q., He, Z., Zubkov, D., Huang, S., Kurochkin, I., Yang, X., Halene, T., Willmitzer, L., Giavalisco, P., Akbarian, S., Khaitovich, P*. Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders. Molecular psychiatry 25 (2020), 2952-2969. IF: 13.437

4. Xu, C., Li, Q., Efimova, O., He, L., Tatsumoto, S., Stepanova, V., Oishi, T., Udono, T., Yamaguchi, K., Shigenobu, S., Kakita, A., Nawa, H., Khaitovich, P*. Human-specific features of spatial gene expression and regulation in eight brain regions. Genome Res 28 (2018), 1097-1110. IF:11.093

5. He, Z., Han, D., Efimova, O., Guijarro, P., Yu, Q., Oleksiak, A., Jiang, S., Anokhin, K., Velichkovsky, B., Grunewald, S., Khaitovich, P. Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques. Nat Neurosci 20 (2017), 886-895. IF: 21.125

6. Li, Q., Bozek, K., Xu, C., Guo, Y., Sun, J., Paabo, S., Sherwood, C.C., Hof, P.R., Ely, J.J., Li, Y., Willmitzer, L., Giavalisco, P., Khaitovich, P*. Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys. Mol Biol Evol 34 (2017), 1155-1166. IF: 14.796

7. Bozek, K., Wei, Y., Yan, Z., Liu, X., Xiong, J., Sugimoto, M., Tomita, M., Paabo, S., Sherwood, C.C., Hof, P.R., Ely, J.J., Li, Y., Steinhauser, D., Willmitzer, L., Giavalisco, P., Khaitovich, P*. Organization and evolution of brain lipidome revealed by large-scale analysis of human, chimpanzee, macaque, and mouse tissues. Neuron 85 (2015), 695-702. IF: 14.024

8. Khrameeva, E.E., Bozek, K., He, L., Yan, Z., Jiang, X., Wei, Y., Tang, K., Gelfand, M.S., Prufer, K., Kelso, J., Paabo, S., Giavalisco, P., Lachmann, M., Khaitovich, P*. Neanderthal ancestry drives evolution of lipid catabolism in contemporary Europeans. Nature communications 5 (2014), 3584. IF: 11.329

9. Mazin, P., Xiong, J., Liu, X., Yan, Z., Zhang, X., Li, M., He, L., Somel, M., Yuan, Y., Phoebe Chen, Y.P., Li, N., Hu, Y., Fu, N., Ning, Z., Zeng, R., Yang, H., Chen, W., Gelfand, M., Khaitovich, P*. Widespread splicing changes in human brain development and aging. Mol Syst Biol 9 (2013), 633. IF: 10.872

10. Khaitovich, P., Hellmann, I., Enard, W., Nowick, K., Leinweber, M., Franz, H., Weiss, G., Lachmann, M., Paabo, S. Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees. Science 309 (2005), 1850-1854. IF: 31.378

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